Spindle assembly involved in female meiosis

Across TCGA cell cohorts, RNA activity of the Spindle assembly involved in female meiosis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZFAND5, ZBTB49, and PELO, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spindle assembly involved in female meiosis activity versus ZFAND5 in LUNG_NSCLC_LUSC (Pearson r = -0.90).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ZFAND5 →	-1.123	-0.200	.003	.004	3	3
LUNG_NSCLC_LUAD	ZBTB49 →	+0.346	+0.143	.006	.007	3	3
BONE	PELO →	-0.716	-0.238	.001	.002	3	3
BONE	ADAMTS1 →	-3.684	-0.220	.001	.003	3	3
BLOOD_Myeloma	PLEKHO2 →	-1.162	-0.236	<.001	.006	3	3
UPPER_AERODIGESTIVE_TRACT	SORBS1 →	-0.555	-0.187	.005	.008	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007056 vs ZFAND5 — LUNG_NSCLC_LUSC

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