Spindle organization

Across TCGA patient cohorts, RNA activity of the Spindle organization pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL12_S38, SMC2, and TOP2A, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spindle organization activity versus RPL12_S38 in LUAD (Pearson r = 0.69).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPL12_S38 →	+1.390	+0.080	<.001	<.001	3	10
LUAD	SMC2 →	+0.757	+0.087	<.001	<.001	3	10
LUAD	TOP2A →	+1.321	+0.092	<.001	<.001	3	10
LUAD	TOP2A_S1106 →	+1.520	+0.086	<.001	<.001	3	10
LUAD	TOP2A_S1247 →	+1.653	+0.084	<.001	<.001	3	10
LUAD	H1-10_S31 →	+1.162	+0.059	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007051 vs RPL12_S38 — LUAD

Explore this scatter interactively →