Cell-cell junction assembly

Across TCGA patient cohorts, RNA activity of the Cell-cell junction assembly pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NID1, RSU1, and ITIH1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell-cell junction assembly activity versus NID1 in CCRCC (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	NID1 →	+0.487	+0.048	<.001	<.001	3	9
UCEC	RSU1 →	+0.518	+0.050	<.001	<.001	3	8
OV	ITIH1 →	+1.126	+0.048	<.001	<.001	3	8
UCEC	LAMA4 →	+0.650	+0.053	<.001	<.001	3	8
CCRCC	LAMC1 →	+0.507	+0.044	.001	<.001	2	9
OV	NID2 →	+0.500	+0.031	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007043 vs NID1 — CCRCC

Explore this scatter interactively →