Cell-cell junction assembly

Across TCGA cell cohorts, RNA activity of the Cell-cell junction assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARNTL, NPHP4, and IFT122, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARNTL grouped by Cell-cell junction assembly-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ARNTL →	-1.125	-1.163	.006	.003	3	4
OVARY	NPHP4 →	-0.538	-0.709	.001	.004	3	3
OVARY	IFT122 →	-0.459	-0.702	.009	.004	3	3
BREAST	FOLR1 →	+2.081	+0.477	.002	.004	3	2
BREAST	SLC35F2 →	+1.443	+0.719	.001	.002	2	3
BREAST	CLDN24 →	+0.091	+0.494	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARNTL by Cell-cell junction assembly activity — LUNG_SCLC

Explore this box plot interactively →