Cell-cell junction assembly

Across TCGA cell cohorts, RNA activity of the Cell-cell junction assembly pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1QBP, PDXP, and MST1R, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell-cell junction assembly activity versus C1QBP in OESOPHAGUS (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	C1QBP →	-1.148	-0.083	.001	.001	2	13
URINARY_TRACT	PDXP →	-2.091	-0.087	<.001	.003	3	11
STOMACH	MST1R →	+2.622	+0.093	.005	.006	3	10
URINARY_TRACT	JUP →	+2.995	+0.062	.003	.009	3	10
OESOPHAGUS	LPAR5 →	+1.991	+0.116	<.001	<.001	3	10
LARGE_INTESTINE	FANK1 →	+1.069	+0.052	<.001	.005	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007043 vs C1QBP — OESOPHAGUS

Explore this scatter interactively →