Lysosomal lumen acidification

Across TCGA patient cohorts, RNA activity of the Lysosomal lumen acidification pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAPRE3, MKI67_S827, and RRP9, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lysosomal lumen acidification activity versus MAPRE3 in UCEC (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAPRE3 →	+0.497	+0.065	<.001	.001	3	7
UCEC	MKI67_S827 →	-0.855	-0.073	<.001	.001	3	7
GBM	RRP9 →	-0.424	-0.071	<.001	<.001	3	7
LUAD	DDX21_S89 →	-1.050	-0.052	<.001	<.001	3	7
LUAD	SMC4 →	-0.474	-0.049	<.001	<.001	3	6
GBM	TOP1 →	-0.308	-0.061	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007042 vs MAPRE3 — UCEC

Explore this scatter interactively →