Lysosomal transport

Across TCGA patient cohorts, RNA activity of the Lysosomal transport pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, RPL10A, and SEPTIN4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lysosomal transport activity versus RPL5 in LUAD (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPL5 →	-0.173	-0.023	<.001	.002	3	9
GBM	RPL10A →	-0.224	-0.040	<.001	.001	3	8
GBM	SEPTIN4 →	+0.658	+0.041	<.001	<.001	3	7
GBM	SEPTIN4_S432 →	+0.617	+0.035	.006	.001	1	9
CCRCC	PRKG1 →	+0.466	+0.028	<.001	.001	3	7
GBM	RRM2 →	-0.748	-0.040	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007041 vs RPL5 — LUAD

Explore this scatter interactively →