Lysosomal transport

Across TCGA pan-cancer cohorts, RNA activity of the Lysosomal transport pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 133 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Lysosomal transport pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and BRCA, show the opposite pattern, with higher activity associated with better survival.

HNSC, KIRC, and BRCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.422	0.255	<.001	137	view →
KIRC	DFS	Tertile	All	0.504	0.676	.001	47	view →
BRCA	DFS	Quartile	III,IV	0.965	0.782	<.001	47	view →
UCS	DFS	Median	IV	0.952	0.473	.018	36	view →
UVM	DFS	Quartile	III,IV	0.187	0.844	.002	34	view →
ESCA	OS	Median	III,IV	0.654	0.317	.002	33	view →
LUSC	DFS	Median	III,IV	0.342	0.997	<.001	33	view →
SCLC	DFS	Quartile	III,IV	0.716	0.240	.006	19	view →
UCEC	OS	Median	IV	0.936	0.614	.009	18	view →
SKCM	OS	Quartile	III,IV	0.485	0.208	.008	15	view →
SARC	OS	Quartile	All	0.647	0.408	.005	14	view →
MESO	DFS	Median	IV	0.242	0.483	.030	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0007041–HNSC (DFS)

Open the HNSC breakdown →