Lysosomal transport

Across TCGA cell cohorts, RNA activity of the Lysosomal transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPAA1, FXR2, and ZDHHC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPAA1 grouped by Lysosomal transport-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GPAA1 →	+0.622	+0.233	.001	<.001	3	5
LARGE_INTESTINE	FXR2 →	-0.532	-0.200	.008	<.001	3	4
LARGE_INTESTINE	ZDHHC1 →	+1.174	+0.172	.005	.003	3	4
BLOOD_Myeloma	KLHDC8B →	-1.302	-0.366	.008	<.001	3	4
BLOOD_Lymphoma	NNT →	+0.960	+0.303	<.001	.005	3	4
BLOOD_Lymphoma	LRRC37B →	+0.724	+0.376	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPAA1 by Lysosomal transport activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →