Lysosomal transport

Across TCGA cell cohorts, RNA activity of the Lysosomal transport pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GASK1B, TPM3, and IL1RAP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lysosomal transport activity versus GASK1B in BREAST (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GASK1B →	+1.971	+0.186	<.001	<.001	3	5
BLOOD_Myeloma	TPM3 →	+0.765	+0.186	.006	.009	2	5
BLOOD_Leukemia	IL1RAP →	+1.206	+0.155	.001	<.001	3	4
KIDNEY	TMEM62 →	-1.194	-0.225	<.001	<.001	3	4
BONE	ARF3 →	+0.518	+0.205	.001	.006	3	4
LIVER	COTL1 →	+4.480	+0.161	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007041 vs GASK1B — BREAST

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