Protein catabolic process in the vacuole

Across TCGA patient cohorts, RNA activity of the Protein catabolic process in the vacuole pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAB39L, NCAPD2, and SNTB2_S222, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein catabolic process in the vacuole activity versus CAB39L in BRCA (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CAB39L →	+0.709	+0.035	<.001	<.001	3	7
GBM	NCAPD2 →	-0.430	-0.043	.003	<.001	3	7
LUAD	SNTB2_S222 →	+0.596	+0.042	<.001	<.001	3	6
UCEC	SLC2A1 →	-0.651	-0.059	.004	.003	3	6
GBM	MKI67_S2828 →	-0.930	-0.058	<.001	<.001	3	6
LUAD	RFC1_S368 →	-0.842	-0.062	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007039 vs CAB39L — BRCA

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