Protein catabolic process in the vacuole

Across TCGA patient cohorts, RNA activity of the Protein catabolic process in the vacuole pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EMC3-AS1, DCLRE1C, and BCL11A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein catabolic process in the vacuole activity versus EMC3-AS1 in HNSC (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	EMC3-AS1 →	-0.530	-0.147	.002	.004	3	4
COAD	DCLRE1C →	-0.370	-0.174	.005	.003	3	4
HNSC	BCL11A →	-0.540	-0.138	.002	.001	3	4
HNSC	GNRH2 →	-0.501	-0.115	<.001	.007	3	4
HNSC	FAM186B →	-0.427	-0.200	.001	<.001	3	4
HNSC	TNXB →	-0.772	-0.155	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007039 vs EMC3-AS1 — HNSC

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