Protein catabolic process in the vacuole

Across TCGA patient cohorts, RNA activity of the Protein catabolic process in the vacuole pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TMEM199, RNF185, and SARAF, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein catabolic process in the vacuole activity versus TMEM199 in UCEC (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TMEM199 →	+0.733	+0.230	<.001	.001	3	4
PDAC	RNF185 →	+0.497	+0.141	<.001	.003	3	3
BRCA	SARAF →	+0.459	+0.190	<.001	<.001	3	3
PDAC	ATP6V0A1 →	+0.325	+0.153	.001	.002	2	4
HNSC	THBS4 →	-1.055	-0.193	<.001	<.001	3	3
CCRCC	TMEM19 →	+0.489	+0.190	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007039 vs TMEM199 — UCEC

Explore this scatter interactively →