Protein catabolic process in the vacuole

Across TCGA cell cohorts, RNA activity of the Protein catabolic process in the vacuole pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACBD4, PLEKHA5, and CYP2J2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACBD4 grouped by Protein catabolic process in the vacuole-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ACBD4 →	+0.796	+0.650	.005	.003	3	4
KIDNEY	PLEKHA5 →	+0.694	+0.950	.006	.002	2	4
LARGE_INTESTINE	CYP2J2 →	+2.344	+0.904	.001	.009	2	4
SKIN	PGBD5 →	-0.665	-0.701	<.001	.004	3	3
CNS	MMP19 →	+1.820	+0.879	<.001	<.001	3	3
CNS	PIM1 →	+1.228	+1.007	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACBD4 by Protein catabolic process in the vacuole activity — BREAST

Explore this box plot interactively →