Protein catabolic process in the vacuole

Across TCGA cell cohorts, RNA activity of the Protein catabolic process in the vacuole pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC14C, RPL26, and MYEOV, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein catabolic process in the vacuole activity versus CDC14C in URINARY_TRACT (Pearson r = -0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CDC14C →	-0.052	-1.271	.003	<.001	3	4
LUNG_SCLC	RPL26 →	-0.834	-0.948	.002	.006	3	3
BLOOD_Lymphoma	MYEOV →	-2.071	-1.161	.003	.005	3	3
PANCREAS	ACTL10 →	+0.920	+0.592	.001	.007	3	3
SKIN	SLC49A4 →	+0.715	+0.169	.007	.008	3	3
LARGE_INTESTINE	NSDHL →	+1.158	+0.891	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007039 vs CDC14C — URINARY_TRACT

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