Vacuolar acidification

Across TCGA patient cohorts, RNA activity of the Vacuolar acidification pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SF3B2, RPS3, and RPS5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vacuolar acidification activity versus SF3B2 in GBM (Pearson r = -0.67).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SF3B2 →	-0.279	-0.083	<.001	<.001	3	7
GBM	RPS3 →	-0.172	-0.055	.001	.001	3	6
LSCC	RPS5 →	-0.133	-0.037	<.001	<.001	3	6
GBM	SIN3A_S860 →	-0.543	-0.096	<.001	<.001	3	6
GBM	AURKB →	-0.835	-0.108	<.001	<.001	3	6
GBM	TOP1 →	-0.332	-0.069	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007035 vs SF3B2 — GBM

Explore this scatter interactively →