Vacuolar acidification

Across TCGA cell cohorts, RNA activity of the Vacuolar acidification pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP6AP1, ATP6V0C, and C1GALT1C1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vacuolar acidification activity versus ATP6AP1 in PANCREAS (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ATP6AP1 →	+1.083	+0.372	<.001	<.001	3	9
PANCREAS	ATP6V0C →	+1.135	+0.316	<.001	<.001	3	8
BLOOD_Leukemia	C1GALT1C1 →	+0.778	+0.248	<.001	<.001	3	5
BLOOD_Leukemia	CRLF3 →	-0.774	-0.154	<.001	.002	3	5
BLOOD_Leukemia	ATP6AP2 →	+0.503	+0.170	<.001	<.001	3	5
SKIN	RPL24 →	-0.984	-0.379	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007035 vs ATP6AP1 — PANCREAS

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