Peroxisome organization

Across TCGA cell cohorts, RNA activity of the Peroxisome organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DCUN1D4, ABRAXAS2, and KLK8, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peroxisome organization activity versus DCUN1D4 in BLOOD_Myeloma (Pearson r = 0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	DCUN1D4 →	+1.316	+1.309	<.001	.002	3	3
BLOOD_Myeloma	ABRAXAS2 →	+0.828	+1.355	.008	.002	3	3
OVARY	KLK8 →	+2.776	+0.664	.003	.003	3	3
OVARY	H4C14 →	+1.635	+0.675	.002	.003	3	3
BLOOD_Leukemia	DAP3 →	+0.436	+0.664	.004	.005	3	3
BLOOD_Leukemia	SLC30A9 →	+0.776	+1.094	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007031 vs DCUN1D4 — BLOOD_Myeloma

Explore this scatter interactively →