Endoplasmic reticulum organization

Across TCGA patient cohorts, RNA activity of the Endoplasmic reticulum organization pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATP1B1, STX12_S142, and SHTN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoplasmic reticulum organization activity versus ATP1B1 in GBM (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ATP1B1 →	+0.505	+0.032	<.001	<.001	3	5
BRCA	STX12_S142 →	+0.453	+0.018	.002	.004	3	5
GBM	SHTN1 →	+0.507	+0.042	<.001	<.001	3	5
LSCC	GORASP2_T222 →	+0.486	+0.029	<.001	<.001	3	5
GBM	ATP6V0A1 →	+0.444	+0.033	<.001	<.001	3	5
CCRCC	TDRKH →	+0.213	+0.022	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007029 vs ATP1B1 — GBM

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