Endoplasmic reticulum organization

Across TCGA patient cohorts, RNA activity of the Endoplasmic reticulum organization pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TMEM120A, EMC3, and SUCO_S1081, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoplasmic reticulum organization activity versus TMEM120A in UCEC (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TMEM120A →	+0.673	+0.276	.002	<.001	3	6
UCEC	EMC3 →	+0.522	+0.217	<.001	<.001	3	6
UCEC	SUCO_S1081 →	+1.066	+0.190	<.001	.002	3	5
UCEC	RPN1 →	+0.754	+0.245	<.001	<.001	3	5
UCEC	SLC25A3 →	+0.848	+0.260	<.001	<.001	3	5
UCEC	ATP13A1 →	+0.650	+0.286	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007029 vs TMEM120A — UCEC

Explore this scatter interactively →