Endoplasmic reticulum organization

Across TCGA cell cohorts, RNA activity of the Endoplasmic reticulum organization pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C3orf18, FRK, and HOXA11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C3orf18 grouped by Endoplasmic reticulum organization-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	C3orf18 →	-1.619	-1.388	.001	<.001	3	4
KIDNEY	FRK →	+0.965	+1.370	.004	<.001	3	4
SOFT_TISSUE	HOXA11 →	+1.583	+1.347	.001	<.001	3	4
SOFT_TISSUE	ACAT1 →	-1.079	-1.037	.001	.007	3	4
LARGE_INTESTINE	MYL9 →	-2.998	-0.734	<.001	.002	3	4
LARGE_INTESTINE	PFDN1 →	-0.433	-0.663	.005	.008	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C3orf18 by Endoplasmic reticulum organization activity — SKIN

Explore this box plot interactively →