Endoplasmic reticulum organization

Across TCGA cell cohorts, RNA activity of the Endoplasmic reticulum organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSPAN15, LAMC2, and CYB561, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoplasmic reticulum organization activity versus TSPAN15 in BLOOD_Lymphoma (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TSPAN15 →	+2.646	+0.204	<.001	.001	3	7
UPPER_AERODIGESTIVE_TRACT	LAMC2 →	+2.834	+0.310	.003	.005	3	7
BLOOD_Lymphoma	CYB561 →	+2.441	+0.204	<.001	<.001	3	6
LIVER	RPS3A →	-0.953	-0.148	.004	.003	3	6
LIVER	ICAM1 →	+1.868	+0.178	.008	<.001	2	7
BLOOD_Lymphoma	PIGK →	+1.343	+0.217	.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007029 vs TSPAN15 — BLOOD_Lymphoma

Explore this scatter interactively →