Post-chaperonin tubulin folding pathway

Across TCGA cell cohorts, RNA activity of the Post-chaperonin tubulin folding pathway pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPNS1, PIK3AP1, and SARAF, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPNS1 grouped by Post-chaperonin tubulin folding pathway-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SPNS1 →	-0.915	-0.173	.001	.008	3	4
STOMACH	PIK3AP1 →	-1.734	-0.299	.006	<.001	3	4
LUNG_SCLC	SARAF →	-1.298	-0.497	.003	<.001	3	3
LUNG_SCLC	EMP3 →	+3.815	+0.303	.003	.008	3	3
LUNG_SCLC	CBLC →	-1.336	-0.324	.007	.001	3	3
LUNG_SCLC	STAR →	-0.287	-0.355	.008	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPNS1 by Post-chaperonin tubulin folding pathway activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →