Microtubule nucleation

Across TCGA cell cohorts, RNA activity of the Microtubule nucleation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEH1L, LEMD1, and BTN2A2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SEH1L grouped by Microtubule nucleation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SEH1L →	+0.731	+0.372	<.001	<.001	3	4
STOMACH	LEMD1 →	+2.990	+0.288	.004	.005	3	4
LUNG_SCLC	BTN2A2 →	-1.235	-0.209	.002	.003	3	3
LUNG_SCLC	MIA →	+1.248	+0.300	.004	.005	3	3
SKIN	RCAN3 →	-0.557	-0.260	.005	.002	3	3
OESOPHAGUS	TIMP3 →	+2.837	+0.202	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SEH1L by Microtubule nucleation activity — BLOOD_Leukemia

Explore this box plot interactively →