Microtubule nucleation

Across TCGA cell cohorts, RNA activity of the Microtubule nucleation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UGCG, NDUFS2, and NAF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule nucleation activity versus UGCG in STOMACH (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	UGCG →	+1.268	+1.202	.004	.002	3	6
BONE	NDUFS2 →	-1.010	-1.163	<.001	.003	3	6
STOMACH	NAF1 →	-0.627	-1.244	.005	.009	2	6
OVARY	ELAC2 →	-0.696	-1.178	<.001	<.001	2	6
OVARY	POLRMT →	-0.637	-0.875	.007	.006	3	5
OVARY	FTO →	-0.934	-1.111	<.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007020 vs UGCG — STOMACH

Explore this scatter interactively →