Outer mitochondrial membrane organization

Across TCGA patient cohorts, RNA activity of the Outer mitochondrial membrane organization pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CENPF_S3023, PAFAH1B3, and MAP7D2_S315, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Outer mitochondrial membrane organization activity versus CENPF_S3023 in LUAD (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CENPF_S3023 →	+1.476	+0.046	<.001	<.001	3	6
LSCC	PAFAH1B3 →	+0.279	+0.036	<.001	.001	3	6
LSCC	MAP7D2_S315 →	+1.336	+0.032	<.001	<.001	3	5
LUAD	SETDB1_S1066 →	+0.754	+0.034	<.001	<.001	3	5
BRCA	SF3B3 →	+0.212	+0.030	<.001	.004	3	5
LUAD	DDX47 →	+0.282	+0.040	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007008 vs CENPF_S3023 — LUAD

Explore this scatter interactively →