Outer mitochondrial membrane organization

Across TCGA cell cohorts, RNA activity of the Outer mitochondrial membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TOMM70, SAMM50, and NIPSNAP1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Outer mitochondrial membrane organization activity versus TOMM70 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TOMM70 →	+0.797	+0.100	.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	SAMM50 →	+1.060	+0.120	.002	.001	3	11
SOFT_TISSUE	NIPSNAP1 →	+0.865	+0.057	.004	.003	2	12
LUNG_NSCLC_LUAD	LRRN2 →	+1.211	+0.115	<.001	<.001	3	10
CNS	TRMT10C →	+0.668	+0.081	<.001	<.001	3	9
LARGE_INTESTINE	ALG12 →	+0.954	+0.088	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007008 vs TOMM70 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →