Nuclear envelope organization

Across TCGA patient cohorts, RNA activity of the Nuclear envelope organization pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ILK, LMNA_S429, and LMNA_S533, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear envelope organization activity versus ILK in UCEC (Pearson r = 0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ILK →	+0.411	+0.103	<.001	.001	3	4
PDAC	LMNA_S429 →	+0.866	+0.158	.001	<.001	3	4
UCEC	LMNA_S533 →	+0.577	+0.168	<.001	<.001	3	4
PDAC	LMNB1_S23 →	+0.859	+0.258	<.001	<.001	3	4
BRCA	RAD21_S545 →	-0.418	-0.134	.001	<.001	3	3
GBM	AATF_S316 →	-1.243	-0.345	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006998 vs ILK — UCEC

Explore this scatter interactively →