Nuclear envelope organization

Across TCGA cell cohorts, RNA activity of the Nuclear envelope organization pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP20, ZNF630, and LTBP3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, USP20 grouped by Nuclear envelope organization-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	USP20 →	+1.097	+0.227	<.001	.001	3	4
PANCREAS	ZNF630 →	+0.718	+0.213	<.001	<.001	3	4
OESOPHAGUS	LTBP3 →	+2.583	+0.239	<.001	<.001	3	4
OESOPHAGUS	ADORA2B →	+1.483	+0.140	.001	<.001	3	4
OESOPHAGUS	MAN1B1 →	+0.968	+0.185	.008	.001	3	4
SOFT_TISSUE	PDZD7 →	+1.259	+0.235	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

USP20 by Nuclear envelope organization activity — PANCREAS

Explore this box plot interactively →