Nuclear envelope organization

Across TCGA cell cohorts, RNA activity of the Nuclear envelope organization pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM32A, SPINDOC, and PIK3CD, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear envelope organization activity versus FAM32A in STOMACH (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FAM32A →	+0.927	+0.158	<.001	.003	3	6
STOMACH	SPINDOC →	+1.128	+0.174	.003	.006	3	6
SKIN	PIK3CD →	+1.830	+0.144	.008	.008	3	5
STOMACH	MED26 →	+0.836	+0.184	.006	.009	3	5
BREAST	ZNF23 →	+0.708	+0.185	<.001	<.001	3	5
LUNG_SCLC	ZNF708 →	+1.186	+0.123	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006998 vs FAM32A — STOMACH

Explore this scatter interactively →