Nucleus organization

Across TCGA patient cohorts, RNA activity of the Nucleus organization pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHL8, TRAV1-2, and CD8A, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleus organization activity versus KLHL8 in COAD (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	KLHL8 →	+0.175	+0.094	.004	.002	3	1
COAD	TRAV1-2 →	+0.669	+0.094	.001	.002	3	1
COAD	CD8A →	+1.244	+0.094	.002	.002	2	1
COAD	C14orf180 →	-0.425	-0.121	.003	.009	2	1
COAD	ZNF682 →	-1.094	-0.094	.002	.002	2	1
COAD	HAUS6P1 →	-0.110	-0.121	.004	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006997 vs KLHL8 — COAD

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