ER-nucleus signaling pathway

Across TCGA cell cohorts, RNA activity of the ER-nucleus signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THOC5, YWHAH, and SPRED2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ER-nucleus signaling pathway activity versus THOC5 in OVARY (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	THOC5 →	-0.623	-0.241	.003	<.001	3	5
OVARY	YWHAH →	-1.108	-0.241	.001	.004	2	6
CNS	SPRED2 →	-0.701	-0.224	.001	.004	3	4
STOMACH	POLA1 →	-0.827	-0.311	.007	.002	2	5
BLOOD_Leukemia	ZNF71 →	-0.723	-0.212	.008	.002	3	4
LARGE_INTESTINE	CMTR1 →	-0.539	-0.234	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006984 vs THOC5 — OVARY

Explore this scatter interactively →