Hypotonic response

Across TCGA patient cohorts, RNA activity of the Hypotonic response pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYLK, LMOD1, and HSPB7, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hypotonic response activity versus MYLK in LSCC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MYLK →	+0.930	+0.328	<.001	<.001	3	9
CCRCC	LMOD1 →	+1.125	+0.271	<.001	<.001	2	8
COAD	HSPB7 →	+0.675	+0.123	.005	.007	3	7
CCRCC	CNN1 →	+1.327	+0.229	<.001	.004	3	7
BRCA	LINC00702 →	+0.363	+0.146	<.001	<.001	3	7
BRCA	FAM180A →	+0.742	+0.209	.006	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006971 vs MYLK — LSCC

Explore this scatter interactively →