Response to osmotic stress

Across TCGA cell cohorts, RNA activity of the Response to osmotic stress pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPTOR, WNK1, and POT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPTOR grouped by Response to osmotic stress-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	RPTOR →	-0.522	-0.340	<.001	<.001	3	6
LUNG_NSCLC_LUSC	WNK1 →	-0.653	-0.351	.003	.001	3	5
UPPER_AERODIGESTIVE_TRACT	POT1 →	+0.168	+0.242	<.001	<.001	3	4
BLOOD_Leukemia	CCL27 →	+0.218	+0.193	.002	<.001	3	4
BONE	CMKLR1 →	+0.279	+0.333	.001	.005	3	4
BLOOD_Leukemia	KRTAP5-2 →	+0.288	+0.292	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPTOR by Response to osmotic stress activity — BLOOD_Myeloma

Explore this box plot interactively →