Response to osmotic stress

Across TCGA cell cohorts, RNA activity of the Response to osmotic stress pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LDHA, TJP3, and SLC20A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to osmotic stress activity versus LDHA in OVARY (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	LDHA →	+2.178	+0.315	<.001	.004	3	6
OVARY	TJP3 →	-1.550	-0.188	.003	.003	3	5
SKIN	SLC20A1 →	+0.959	+0.189	.005	.008	3	5
BONE	DIPK1A →	+1.896	+0.389	.005	.001	3	5
BONE	FAT1 →	+4.044	+0.367	.007	.004	3	5
LUNG_NSCLC_LUAD	VEGFC →	+1.223	+0.160	.008	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006970 vs LDHA — OVARY

Explore this scatter interactively →