Response to osmotic stress

Across TCGA cell cohorts, RNA activity of the Response to osmotic stress pathway is significantly associated with the protein abundance of multiple proteins, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKR1B1, GBE1, and LIMS1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to osmotic stress activity versus AKR1B1 in LIVER (Pearson r = 0.79).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	AKR1B1 →	+2.324	+0.258	.008	.006	3	9
SKIN	GBE1 →	+0.922	+0.228	<.001	.001	3	9
BONE	LIMS1 →	+1.758	+0.309	<.001	.001	3	8
BONE	CAPNS1 →	+1.055	+0.304	.001	<.001	3	7
LUNG_NSCLC_LUSC	ACTR2 →	+1.015	+0.322	.006	.009	3	7
CNS	CAST →	+1.110	+0.150	.006	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006970 vs AKR1B1 — LIVER

Explore this scatter interactively →