Complement activation

Across TCGA patient cohorts, RNA activity of the Complement activation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are A1BG, SELENOP, and SERPINA1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Complement activation activity versus A1BG in CCRCC (Pearson r = 0.66).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	A1BG →	+0.617	+0.250	<.001	<.001	3	10
UCEC	SELENOP →	+0.718	+0.341	<.001	<.001	3	10
OV	SERPINA1 →	+0.990	+0.474	<.001	<.001	3	10
CCRCC	SERPINA10 →	+0.681	+0.271	<.001	<.001	3	10
COAD	SERPINA3 →	+0.835	+0.386	<.001	<.001	3	10
BRCA	SERPINA4 →	+0.699	+0.381	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006956 vs A1BG — CCRCC

Explore this scatter interactively →