Acute-phase response

Across TCGA patient cohorts, RNA activity of the Acute-phase response pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are S100A9, UNC13D, and PRAM1_S484, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acute-phase response activity versus S100A9 in UCEC (Pearson r = 0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S100A9 →	+1.176	+0.093	<.001	<.001	3	8
GBM	UNC13D →	+0.589	+0.140	<.001	<.001	3	7
UCEC	PRAM1_S484 →	+0.852	+0.091	<.001	<.001	3	7
LSCC	DYSF →	+0.491	+0.090	<.001	<.001	3	7
BRCA	S100A12 →	+1.313	+0.049	<.001	<.001	3	7
UCEC	S100A8 →	+1.260	+0.087	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006953 vs S100A9 — UCEC

Explore this scatter interactively →