Acute-phase response

Across TCGA pan-cancer cohorts, RNA activity of the Acute-phase response pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 48 member genes.

The strongest signal is observed in thymoma (THYM), where higher Acute-phase response pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as MESO and SKCM, show the opposite pattern, with higher activity associated with better survival.

THYM, GBM, and MESO are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Tertile	All	0.598	0.968	<.001	35	view →
GBM	DFS	Median	All	0.175	0.371	.002	31	view →
MESO	DFS	Median	III,IV	0.588	0.297	.002	31	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	30	view →
LGG	OS	Tertile	All	0.387	0.569	<.001	29	view →
SKCM	OS	Median	All	0.865	0.712	.002	25	view →
SCLC	DFS	Tertile	II,III,IV	0.357	0.687	.006	14	view →
PRAD	DFS	Quartile	All	0.964	0.887	.025	12	view →
TGCT	DFS	Tertile	II,III,IV	0.670	1.000	.045	12	view →
LUSC	OS	Quartile	All	0.716	0.796	.020	12	view →
BRCA	OS	Median	IV	0.541	0.861	.026	11	view →
KIRC	DFS	Tertile	IV	0.841	0.490	.006	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0006953–THYM (OS)

Open the THYM breakdown →