Acute-phase response

Across TCGA patient cohorts, RNA activity of the Acute-phase response pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDPN, LILRB3, and DSE, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acute-phase response activity versus PDPN in LSCC (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PDPN →	+0.649	+0.097	.006	.001	3	7
COAD	LILRB3 →	+0.869	+0.243	<.001	.003	3	6
OV	DSE →	+0.605	+0.137	<.001	<.001	3	5
COAD	AQP9 →	+1.250	+0.234	.001	.004	3	5
OV	ZEB2 →	+0.754	+0.212	<.001	<.001	3	5
LUAD	HIF1A →	+0.520	+0.155	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006953 vs PDPN — LSCC

Explore this scatter interactively →