Acute-phase response

Across TCGA cell cohorts, RNA activity of the Acute-phase response pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMOX1, ADM, and NDUFS7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acute-phase response activity versus HMOX1 in CNS (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	HMOX1 →	+1.803	+0.299	.001	.007	3	6
KIDNEY	ADM →	+2.247	+0.390	.004	.007	3	5
BONE	NDUFS7 →	-0.815	-0.206	.002	.004	3	4
STOMACH	HDAC1 →	-0.861	-0.273	<.001	.005	3	4
LUNG_NSCLC_LUSC	MANSC1 →	-2.727	-0.342	<.001	.008	3	4
BREAST	BTG2 →	-1.890	-0.286	.002	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006953 vs HMOX1 — CNS

Explore this scatter interactively →