Striated muscle contraction

Across TCGA patient cohorts, RNA activity of the Striated muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EOGT, ITGB3, and ARHGAP21, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Striated muscle contraction activity versus EOGT in BRCA (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EOGT →	+0.978	+0.664	.001	.007	3	3
BRCA	ITGB3 →	+0.794	+0.712	.002	.001	3	3
BRCA	ARHGAP21 →	+0.779	+0.719	<.001	.009	3	2
BRCA	VEGFA →	+0.813	+0.676	.001	.002	3	2
BRCA	SLC39A1 →	+0.630	+0.998	<.001	<.001	3	2
BRCA	FBXO32 →	+1.474	+0.749	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006941 vs EOGT — BRCA

Explore this scatter interactively →