Striated muscle contraction

Across TCGA cell cohorts, RNA activity of the Striated muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MARK2, NELFA, and HK2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Striated muscle contraction activity versus MARK2 in BLOOD_Lymphoma (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MARK2 →	-0.469	-0.118	.008	.008	3	6
LUNG_SCLC	NELFA →	-0.514	-0.159	.004	.003	3	5
BLOOD_Lymphoma	HK2 →	-1.921	-0.195	<.001	.001	3	5
OVARY	RIN3 →	+2.197	+0.294	<.001	.001	3	5
BLOOD_Lymphoma	PLP2 →	+1.757	+0.167	<.001	.002	3	5
BLOOD_Lymphoma	ZYX →	+3.060	+0.190	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006941 vs MARK2 — BLOOD_Lymphoma

Explore this scatter interactively →