Smooth muscle contraction

Across TCGA patient cohorts, RNA activity of the Smooth muscle contraction pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RSU1, SERPINA4, and SPARCL1_S295, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Smooth muscle contraction activity versus RSU1 in UCEC (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RSU1 →	+0.461	+0.056	<.001	<.001	3	10
OV	SERPINA4 →	+0.701	+0.036	<.001	<.001	3	10
OV	SPARCL1_S295 →	+0.905	+0.032	.004	.003	3	10
GBM	SSC5D →	+0.803	+0.046	<.001	<.001	3	10
OV	TNS1 →	+0.925	+0.042	.002	<.001	3	10
UCEC	VCL →	+0.510	+0.058	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006939 vs RSU1 — UCEC

Explore this scatter interactively →