Smooth muscle contraction

Across TCGA patient cohorts, RNA activity of the Smooth muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKG1, ACTA2, and SYNPO2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Smooth muscle contraction activity versus PRKG1 in UCEC (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRKG1 →	+1.145	+1.506	<.001	<.001	3	9
UCEC	ACTA2 →	+1.913	+1.304	.001	<.001	3	8
UCEC	SYNPO2 →	+1.729	+1.581	<.001	<.001	3	8
UCEC	MSRB3 →	+1.339	+1.156	<.001	.002	3	8
UCEC	MYLK →	+1.273	+1.504	<.001	<.001	3	8
UCEC	CNN1 →	+2.450	+1.568	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006939 vs PRKG1 — UCEC

Explore this scatter interactively →