Smooth muscle contraction

Across TCGA cell cohorts, RNA activity of the Smooth muscle contraction pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are YWHAE, SFRP1, and RAB35, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, YWHAE grouped by Smooth muscle contraction-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	YWHAE →	+0.189	+0.097	.005	.001	3	5
BREAST	SFRP1 →	+0.322	+0.115	<.001	<.001	3	4
BLOOD_Leukemia	RAB35 →	+0.440	+0.112	.002	.003	3	4
BLOOD_Leukemia	SNRPD1 →	+0.358	+0.115	.006	.002	3	4
LUNG_NSCLC_LUAD	NLE1 →	-0.275	-0.111	.001	.003	3	4
LARGE_INTESTINE	CYP7A1 →	-0.180	-0.110	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

YWHAE by Smooth muscle contraction activity — SOFT_TISSUE

Explore this box plot interactively →