Regulation of muscle contraction

Across TCGA patient cohorts, RNA activity of the Regulation of muscle contraction pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC4, RSU1, and SPARCL1_S198, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of muscle contraction activity versus RFC4 in LSCC (Pearson r = -0.53).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RFC4 →	-0.517	-0.045	<.001	<.001	3	9
BRCA	RSU1 →	+0.428	+0.021	<.001	<.001	3	9
UCEC	SPARCL1_S198 →	+1.391	+0.042	<.001	<.001	3	9
GBM	SNX9 →	+0.358	+0.042	<.001	<.001	3	9
GBM	TLN1 →	+0.460	+0.054	<.001	<.001	3	9
BRCA	COL4A1 →	+0.584	+0.027	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006937 vs RFC4 — LSCC

Explore this scatter interactively →