"Substrate-dependent cell migration, cell extension"

Across TCGA patient cohorts, RNA activity of the "Substrate-dependent cell migration, cell extension" pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MYH14, ACTR3, and PLEKHA5_S568, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Substrate-dependent cell migration, cell extension" activity versus MYH14 in HNSC (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MYH14 →	+0.430	+0.065	.009	.001	3	5
GBM	ACTR3 →	+0.129	+0.048	.006	.001	3	5
PDAC	PLEKHA5_S568 →	+0.436	+0.028	.001	.009	3	5
LSCC	UIMC1_S677 →	-0.471	-0.063	<.001	.002	3	5
COAD	LARP1 →	-0.195	-0.030	.004	.004	3	5
LSCC	TP53BP2_S486 →	+0.629	+0.050	.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006930 vs MYH14 — HNSC

Explore this scatter interactively →