Substrate-dependent cell migration

Across TCGA cell cohorts, RNA activity of the Substrate-dependent cell migration pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKLE2, PGAM5, and LCORL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ANKLE2 grouped by Substrate-dependent cell migration-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ANKLE2 →	+0.846	+1.233	.008	.004	3	4
BONE	PGAM5 →	+1.031	+1.240	.003	.003	3	4
BLOOD_Myeloma	LCORL →	-1.582	-1.997	<.001	<.001	3	4
BONE	WDR12 →	+0.796	+1.472	.004	.003	3	4
BONE	EXOSC10 →	+0.886	+1.688	<.001	.001	3	4
BREAST	DOCK7 →	-0.711	-0.807	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ANKLE2 by Substrate-dependent cell migration activity — BONE

Explore this box plot interactively →