Pinocytosis

Across TCGA cell cohorts, RNA activity of the Pinocytosis pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPT1, CDC42, and PCBP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPT1 grouped by Pinocytosis-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PPT1 →	-0.292	-1.795	.004	<.001	2	7
LIVER	CDC42 →	-0.488	-1.549	.005	.003	3	6
SOFT_TISSUE	PCBP1 →	+0.475	+1.196	<.001	.002	3	4
SOFT_TISSUE	SULT1C2 →	-0.163	-0.968	.001	.006	3	4
URINARY_TRACT	COPZ1 →	-0.652	-1.720	.005	<.001	3	4
URINARY_TRACT	CLK1 →	-0.206	-1.545	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPT1 by Pinocytosis activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →